Table 2.

Summary of SNPs in MDM2, TP53 and CDKN2A in 192 benign and malignant connective tissue tumors

MDM2CDKN2ACDKN2ACDKN2A
HistopathologyNumberTP53 R72P (CC/CG/GG)*TP53 PIN3 (ii/io/oo)SNP309 (GG/TG/TT)rs11515 (Het)rs3088440 (Het)rs3731249 (A148T [het])
Benign
Desmoid-type fibromatosis110/4/70/0/110/5/6100 (11)
Lipoma141/5/80/2/120/3/11200 (11)
Myxoma21/0/10/1/11/1/0100 (2)
Schwannoma71/3/30/1/65/1/1 (71%)100 (5)
Solitary fibrous tumor30/2/10/1/20/0/3211 (2)
373/14/200/5/326/10/21711 (31)
Total benign(19%)(8/38/54%)(0/14/86%)(16/27/57%(23%)(3%)(3%)
Malignant
Chondrosarcoma120/8/40/4/82/7/3 (17%)200 (7)
DFSP20/0/20/0/20/0/2000 (1)
Ewing's sarcoma162/7/7 (13%)1/6/9 (6%)1/10/5 (6%)201 (11)
Leiomyosarcoma234/6/13 (17%)3/3/17 (13%)3/6/14 (13%)211 (18)
Myxoid LPS224/6/12 (18%)0/3/192/7/13 (9%)300 (16)
WDLPS200/5/150/3/1710/5/5 (50%)201 (13)
DDLPS81/2/5 (13%)1/1/6 (13%)1/3/4 (13%)100 (7)
Osteosarcoma170/6/111/2/14 (6%)3/7/7 (18%)300 (10)
MPNST41/0/3 (25%)0/0/41/2/1 (25%)000 (2)
MFH221/10/11 (5%)0/8/145/10/7 (23%)200 (20)
Synovial sarcoma91/5/3 (11%)0/1/81/4/4 (11%)000 (6)
15514/55/866/31/11829/61/6517
Total malignant(81%)(9/35/56%)(4/20/76%)(19/39/42%(16%)1 (1%)3 (111) (3%)
19217/69/1066/36/15035/71/862424
Total(100%)(9/36/55%)(3/19/78%)(18/37/45%)(17%)(1.4%)(142) (3%)
  • *R72 = GG, P72 = CC.

  • †Number of samples shown in parentheses.