Table 1.

Patient demographics, tumor diagnoses, performance status, and prior therapies at baseline

Patient characteristicsNo. patients
Total no.16
Age (years)
Median in different dose levels50.2–59.8
Range36–72
Male/female10/6
Primary tumor site
NSCLC1
Colorectal3
Breast1
Cervical2
Squamous cell carcinoma3
Undifferentiated carcinoma1
Poorly differentiated carcinoma1
Cholangiocarcinoma1
Oesophageal adenocarcinoma2
Fibrosarcoma1
Eastern Cooperative Oncology Group performance status
02
113
20
No. of prior chemotherapy regimens
00
15
24
≥39
No. prior immunotherapy regimens
016
10
No. prior investigational agents
013
12
21
Prior radiation therapy13
Prior surgery15