Table 1.

Combination index values for effects of Dasatinib and Nutlin-3 on patient B-CLL cell viability, evaluated after 48 hours of treatment

B-CLL patient no.ED50ED75ED90Average CI*
10.830.250.080.39
20.860.460.260.53
30.320.510.830.55
40.850.750.660.75
50.360.490.910.59
6>1>1>1>1
70.360.490.820.56
80.480.350.260.36
91.600.410.130.71
100.430.811.530.92
110.240.310.460.34
120.120.252.10.82
130.240.0021.17e−5<0.1
140.330.270.280.29
150.300.701.620.87
160.260.050.010.11
170.300.320.370.33
180.790.821.000.87
190.500.551.230.76
200.270.270.280.27

NOTE: ED indicates effect dose.

*The average combination index (CI) values were calculated from ED50, ED75, and ED90.