Association of 12 prostate cancer susceptibility SNPs with risk of metastatic prostate cancer, Consortium on genetic risk of metastatic and recurrent prostate cancer
| SNP | Gene | Alleles | India (Cornell U) | Wash U | PLCO | Summary | Summary |
|---|---|---|---|---|---|---|---|
| RR (95% CI)* | RR (95% CI)* | RR (95% CI)* | RR (95% CI)† | RR (95% CI)† | |||
| (212 cases and 1,442 controls) Caucasians only | (470 cases and 1,945 controls) All study participants | ||||||
| rs10486567 | JAZF1 | C/T | 0.59 (0.41–0.85) | 0.74 (0.57–0.97) | 1.21 (0.77–1.89) | 0.98 (0.69–1.41) | 0.79 (0.55–1.12) |
| rs10896449 | 11q13 | G/A | 0.70 (0.52–0.94) | 0.82 (0.65–1.04) | 1.16 (0.80–1.71) | 0.95 (0.65–1.37) | 0.85 (0.66–1.10) |
| rs10993994 | MSMB | C/T | 1.41 (1.02–1.95) | 1.21 (0.96–1.53) | 1.12 (0.75–1.66) | 1.18 (0.96–1.51) | 1.24 (1.05–1.48) |
| rs12771728 | 10q23 | T/C | 1.15 (0.83–1.59) | 1.07 (0.83–1.38) | 1.21 (0.82–1.79) | 1.10 (0.86–1.41) | 1.12 (0.94–1.34) |
| rs4072111 | IL16 | C/T | 0.97 (0.71–1.33) | 0.90 (0.59–1.37) | 0.88 (0.46–1.70) | 0.88 (0.59–1.32) | 0.94 (0.74–1.18) |
| rs4242382 | 8q24 | G/A | 1.38 (0.95–2.02) | 1.47 (1.08–1.98) | 1.24 (0.68–2.26) | 1.31 (0.98–1.91) | 1.40 (1.13–1.75) |
| rs4430796 | HNF1B | T/C | 1.05 (0.77–1.43) | 0.80 (0.64–1.00) | 1.02 (0.68–1.52) | 0.92 (0.71–1.18) | 0.91 (0.76–1.09) |
| rs4782726 | CDH13 | G/A | 0.57 (0.37–0.89) | 1.04 (0.78–1.38) | 0.90 (0.53–1.51) | 0.93 (0.67–1.30) | 0.83 (0.57–1.21) |
| rs4961199 | CPNE3 | G/A | 1.50 (0.48–4.72) | 1.10 (0.77–1.55) | 0.49 (0.24–1.00) | 0.81 (0.33–1.96) | 0.90 (0.50–1.63) |
| rs4962416 | CTBP2 | A/G | 1.26 (0.91–1.73) | 1.01 (0.78–1.31) | 1.05 (0.81–1.31) | 1.02 (0.78–1.32) | 1.10 (0.89–1.36) |
| rs6982080 | 8p21 | G/T | 1.03 (0.75–1.42) | 1.04 (0.82–1.34) | 0.79 (0.51–1.23) | 0.93 (0.72–1.20) | 0.99 (0.83–1.18) |
| rs6983267 | 8q24 | G/T | 0.88 (0.65–1.19) | 0.59 (0.45–0.77) | 0.55 (0.37–0.83) | 0.55 (0.43–0.71) | 0.67 (0.50–0.89) |
NOTE: All I2 statistics were < 20%, indicating no strong evidence of heterogeneity among studies.
↵*RR per risk allele assuming a log-additive model, adjusted for age, and race (Wash U only).
↵†The summary RRs and 95% CIs were calculated using a random-effects model, based on Caucasians only.
↵†The summary RRs and 95% CIs were calculated using a random-effects model, based on all study populations.