Table 1.

Somatic PIK3CA mutations in EECs

CaseTumor histologyTumor stageTumor gradePIK3CA mutation
LocationNucleotide ChangePredicted protein ChangeEffect on FunctionaPreviously reported
In other cancersIn EEC or NEEC
T87EndometrioidIBII/IIIExon 1c.G353AG118DYesNo
T88EndometrioidIBIExon 1c.G263AR88QActivating28YesYes
Exon 12c.C2001AF667LNoNo
Intron 6c.1252–9 C>ANot
determined
T89EndometrioidIIIAIExon 1c.A331GK111EActivatingbYesNo
T92EndometrioidIBIExon 1c.G278AR93QYesNo
Exon 20c.C3074AT1025NYesNo
T94EndometrioidIAIExon 1c.G317TG106VActivatingbYesNo
Exon 5c.G1090AG364RNoNo
T96EndometrioidIAIExon 20c.A3140GH1047RActivating10,31,32YesYes
T97EndometrioidIIBIIExon 1c.G263AR88QActivating28YesYes
Exon 20c.A3062GY1021CYesYes
T99EndometrioidIAIExon 1c.del 325_327 GAAdel E109YesNo
T101EndometrioidIBIExon 7c.T1258CC420RActivating32YesNo
Exon 20c.A3140GH1047RActivating10,31,32YesYes
T102EndometrioidIBIIExon 7c.del 1343_1363del P449-L455ActivatingbNoNo
T103EndometrioidIBIIExon 9c.G1624AE542KActivating32YesYes
T115EndometrioidIBIExon 20c.A3118TM1040LNoNo
Exon 20c.A3140GH1047RActivating10,31,32YesYes
T116EndometrioidIAIIExon 1c.C277GR93WActivatingbYesNo
T117EndometrioidIBIExon 9c.A1633GE545KActivating32YesYes
T118EndometrioidIIAIExon 20c.A3140GH1047RActivating10,31,32YesYes
T121EndometrioidIAIExon 9c.A1634GE545GActivating32YesYes
T122EndometrioidICIIExon 20c.A3140GH1047RActivating10,31,32YesYes
T123EndometrioidIBIExon 9c.C1636AQ546KActivating32YesYes
T131EndometrioidIIBIIIExon 1c.C277TR93WActivatingbYesNo
T132EndometrioidIBIExon 20c.G3012TM1004IYesNo
T133EndometrioidIBIExon 20c.G3145CG1049RActivating28YesYes
T134EndometrioidICIExon 9c.G1633AE545KActivating32YesYes
Exon 20c.A3127GM1043VActivating32YesYes
  • aIndicates the appropriate reference.

  • bMutation shown to be activating in this study (Rudd and colleagues).