Table 2.

Somatic PIK3CA mutations in NEECs

CaseTumor histologyTumor StagePIK3CA mutation
LocationNucleotide ChangePredicted protein ChangeEffect on FunctionaPreviously reported
In other cancersIn EEC or NEEC
OM1323SerousIExon 1c.G241AE81KYesNo
Intron 3c.562+23 C>ANot determined
Intron 8c.1404+10 T>GNot determined
OM2009SerousIExon 9c.A1634CE545AActivating32YesYes
T29SerousIBExon 9c.G1624AE542KActivating32YesYes
T41SerousIIIAExon 1del c.45–c.67 insdelL15_V22insHPINoNo
TCCAA
T49SerousIIBExon 9c.G1624CE542QYesYes
T53SerousIBExon 9c.A1637CQ546PActivating32YesNo
T68SerousIIAExon 1c.G263AR88QActivating28YesYes
Exon 1R108HActivating28YesYes
T69SerousIIIAExon 20c.T3132AN1044KYesYes
T71SerousIBExon 5c.G1093AE365KActivating28YesYes
T74SerousIBExon 20c.C3139TH1047YActivating32YesYes
Exon 1c.G278AR93QYesNo
Exon 1c.G333TK111NActivating32YesNo
T75SerousIIIAExon 20c.A3172TI1058FYesYes
Exon 20c.A3207GX1069_X1069insWYesYes
KDN
T76SerousIAExon 7c.G1357AE453KActivatingbYesNo
Intron 7c.1404+3insTNot determined
T78SerousIBExon 1c.A331GK111EActivatingbYesNo
T79SerousIBExon 20c.C3075AT1025AYesYes
T80SerousIIIAExon 1c.G263AR88QActivating28YesYes
T81SerousIBExon 20c.A3140GH1047RActivating10,31,32YesYes
T59Clear cellIIIAExon 4c.T1031CV344AYesNo
Exon 1c.G263AR88QActivating28YesYes
T61Clear cellICExon 7c.A1358CE453ANoNo
T63Clear cellIIBExon 20c.C3197TA1066VYesYes
Exon 1c.G278AR93QYesNo
T77Clear cellICExon 20c.A3140GH1047RActivating10,31,32YesYes
T82Clear cellIVBExon 1c.G316CG106RActivatingbNoNo
T113Clear cellIBExon 3c.C665TA222VNoNo
Exon 5c.G1093AE365KActivating28YesYes
  • aIndicates the appropriate reference.

  • bMutation shown to be activating in this study (Rudd and colleagues).