Table 1.

Summary of Bliss scores and activity of navitoclax, paclitaxel, or combination treatment in NSCLC cell lines (n = 51)

Cell lineAVG Bliss sumSD of Bliss sum% Inhibition of navitoclax at 3.3 μmol/LSD of % inhibition of navitoclax% Inhibition of paclitaxel at 0.1 μmol/LSD of % inhibition of paclitaxel% Inhibition of navitoclax at 3.3 μmol/L and paclitaxel at 0.1 μmol/LSD of % inhibition of drug combination
LXFL 52962212319.73.451.410.597.80.1
Hop924985245.08.938.42.497.60.1
H226455766.010.535.214.884.79.5
SW1573377114.81.267.02.597.32.7
H322T3584317.99.957.07.183.65.6
H4413538725.511.551.71.890.83.3
H14353114871.93.326.64.987.36.9
SK-MES-130550.80.875.51.697.40.5
H2030304631.22.158.311.286.44.4
H1651298177.72.861.15.790.91.3
H650285481.22.157.416.175.08.8
H1573263719.18.051.118.681.25.9
H1993261403.24.573.36.192.63.5
Hop182424239.13.347.74.991.02.2
Calu-12383213.48.766.04.091.62.4
A549237179.43.070.24.397.40.5
Calu62367825.32.874.54.294.82.4
H169323612846.813.433.08.171.35.3
H34523316393.02.728.516.795.92.1
H520219235.17.279.42.895.10.5
H11552191368.64.381.04.098.51.7
H165021811829.41.978.14.995.71.4
H20732155746.68.226.59.883.54.2
H3582083010.04.180.81.394.21.3
H19752051416.19.786.91.694.80.3
H1299201120.30.661.54.591.41.8
H647198763.20.862.73.094.70.0
H29217822.93.084.35.398.50.7
H17931594837.91.138.95.569.74.4
H2122156560.91.394.42.296.01.8
H821484541.016.890.63.495.14.4
H21261471111.61.368.02.675.12.2
H2009146269.49.073.64.493.11.1
H13551405218.61.180.92.393.40.9
H17921331320.43.180.95.390.42.4
Hop62131623.02.071.70.492.23.1
H231232128.82.881.52.692.11.3
H522120121.82.683.82.790.72.2
H194411413560.319.877.76.687.36.1
H661101120.00.090.62.395.10.4
RERF-LC-MS986721.69.987.05.794.41.1
H1048984978.06.484.57.693.45.8
H13739514333.49.646.08.973.32.1
H4609450.00.090.10.296.20.6
H143785264.02.284.06.588.65.7
H1568822827.12.991.40.594.70.3
H83869401.72.492.31.696.40.9
EBC-167120.91.291.22.296.50.1
H166651140.00.065.815.474.39.9
A427467365.914.275.68.387.45.9
H170344270.00.093.73.597.12.3

NOTE: Bliss expectation was calculated with the equation (A + B) − A × B, where A and B are the fractional growth inhibitions of drug A and B at a given dose. The difference between the Bliss expectation and the observed growth inhibition of the combination of drugs A and B at the same dose is the “Bliss excess.” Bliss excess values were summed across the dose matrix to generate the Bliss sum.