Table 2.

Survival analysis for ovarian clear cell carcinoma patients (n = 50)

Univariate (Kaplan–Meier) analysis (log-rank test) for PFS
VariablenEventsMedian PFS in months (95% CI)P (log-rank)
Genomic cluster1231711 (3 to19)0.009
2271265 (22 to 108)
Genomic patternSimplex19939 (13 to 63)0.258
Complex312014 (0 to 50)
FIGO stageI261165 (39 to 91)0.001
II/III/IV24189 (1 to 16)
Age30–4911465 (0 to 141)0.122
50–69342138 (7 to 69)
70+549 (5 to 13)
Optimal debulkingYes412050 (20 to 79)<0.001
(<2cm residual disease)No992.5 (2 to 3)
ChemotherapyYes402620 (5 to 34)0.433
No10665 (33 to 97)
Nuclear pleomorphismSevere311723 (0 to 58)0.172
Moderate161220 (0 to 57)
Mild30-
NecrosisYes352123 (0 to 57)0.826
No15840 (0 to 110)
Adeno-fibroma likeYes10565 (0 to 172)0.404
No402423 (0 to 57)
InflammationYes11838 (0 to 77)0.661
No392123 (0 to 57)
Mitotic count≤2271465 (0 to 136)0.243
>2231520 (6 to 33)
Univariate (Kaplan–Meier) analysis (log-rank test) for OCS
VariablenEventsMedian OCS in months (95% CI)P (log-rank)
Genomic Cluster1231519 (0 to 69)0.065
2271266 (45 to 87)
Genomic PatternSimplex19959 (32 to 85)0.492
Complex311867 (6 to 128)
FIGO StageI261075 (62 to 88)0.001
II/III/IV241715 (4 to 26)
Age30–4911417 (34 to101)0.179
50–69342015 (29 to 89)
70+53-
Optimal debulkingYes411967 (57 to 78)<0.001
(<2cm residual disease)No987 (1 to 14)
ChemotherapyYes402159 (19 to 98)0.780
No10667 (36 to 99)
Nuclear pleomorphismSevere311663 (14 to113)0.230
Moderate161151 (27 to 76)
Mild30-
NecrosisYes351963 (33 to 93)0.962
No15851 (0 to121)
Adeno-fibroma likeYes10571 (48 to 95)0.469
No402251 (22 to 80)
InflammationYes11843 (0 to 92)0.406
No391966 (43 to 90)
Mitotic count≤2271367 (41 to 94)0.336
>2231443 (4 to 82)
Multivariate (Cox regression) analysis for PFS and OCS
HR (95% CI)P
PFS
Clusters (1 vs 2)0.389 (0.174, 0.872)0.022
FIGO Stage (I vs II/III/IV)2.299 (0.919, 5.750)0.075
Residual Disease (<2cm vs ≥2cm)6.660 (2.170, 20.442)0.001
OCS
Clusters (1 vs 2)0.524 (0.223, 1.228)0.137
FIGO Stage (I vs II/III/IV)2.946 (1.121, 7.744)0.028
Residual Disease (<2cm vs ≥2cm)5.627 (1.649, 19.199)0.006