Table 2.

Correlations between in vitro growth inhibition defined as IC50 values following PD-0332991 treatment and the relative expression of selected biomarkers implicated in CDK4/6 signaling pathways in 40 ovarian cancer cell lines

NameSymbolProbe numberCorrelation coefficientaP
p16/INK4ACDKN2AA_23_P434900.690.000
Cyclin ECCNE1A_23_P2092000.580.000
Transcription factor E2F1E2F1A_23_P800320.470.002
Cyclin-dependent kinase 1CDK1A_23_P1385070.410.008
p19/INK4DCDKN2DA_23_P899410.400.010
Thymidine kinase 1TK1A_23_P1074210.330.036
p15/INK4BCDKN2BA_24_P3606740.330.037
p18/INK4CCDKN2CA_23_P854600.250.118
Cyclin E2CCNE2A_23_P2159760.200.225
Retinoblastoma-like protein 1 (p107)RBL1A_23_P287330.170.284
Cyclin D1CCND1A_24_P1245500.070.671
Cyclin-dependent kinase 6CDK6A_23_P1686510.040.814
Cdk inhibitor 1B, p27, Kip1CDKN1BA_23_P2046960.000.986
Cyclin D2CCND2A_24_P270235−0.080.603
Cyclin D3CCND3A_23_P214464−0.120.443
Cyclin-dependent kinase 4CDK4A_23_P24997−0.140.392
Cdk inhibitor 1A, p21, Cip1, WAF1CDKN1AA_24_P89457−0.380.016
Retinoblastoma-like protein 2 (p130)RBL2A_23_P26413−0.390.014
Retinoblastoma 1 (p105)RBA_23_P204850−0.420.007
  • aSpearman's rho correlation.