Table 2.

Analysis of the association between ERCC1 rs11615C>T and ERCC2 rs13181T>G polymorphisms and objective response, PFS, and OS

 Objective responsePFSOS
Studya (cases)T/T + T/C vs. C/CPhetbStudy (cases)T/T + T/C vs. C/CPhetbStudy (cases)T/T + T/C vs. C/CPhetb
Fixed effectRandom effectFixed effectRandom effectFixed effectRandom effect
ERCC1 rs11615C>T
 All9 (855)0.81 (0.58–1.12)0.89 (0.50–1.57)0.00511 (1,230)1.33 (1.15–1.54)1.33 (0.94–1.87)<0.0019 (968)1.53 (1.27–1.85)1.51 (1.02–2.24)<0.001
 Asian4 (378)0.53 (0.35–0.81)0.55 (0.31–0.98)0.1585 (504)1.79 (1.45–2.21)1.69 (1.05–2.70)<0.0015 (504)2.03 (1.60–2.59)1.95 (1.37–2.78)0.078
 Caucasian5 (477)1.47 (0.89–2.43)1.44 (0.68–3.02)0.1036 (726)1.00 (0.81–1.23)1.07 (0.72–1.59)0.0044 (464)0.97 (0.72–1.32)1.10 (0.60–2.03)0.012
 Colorectal only7 (707)0.77 (0.54–1.12)0.88 (0.42–1.87)0.0028 (993)1.38 (1.17–1.64)1.39 (0.89–2.17)<0.0016 (731)1.58 (1.27–1.98)1.55 (0.87–2.77)<0.001
ERCC2 rs13181T>GG/G + G/T vs. T/TG/G + G/T vs. T/TG/G + G/T vs. T/TG/G + G/T vs. T/TG/G + G/T vs. T/TG/G + G/T vs. T/T
 All6 (625)0.53 (0.37–0.78)0.53 (0.36–0.78)0.5888 (931)1.37 (1.15–1.63)1.41 (1.06–1.89)0.0106 (669)1.61 (1.29–2.00)1.54 (0.96–2.50)<0.001
 Asian2 (261)2 (261)2 (261)
 Caucasian4 (364)0.56 (0.35–0.88)0.56 (0.35–0.89)0.3686 (670)1.33 (1.09–1.62)1.41 (1.02–1.95)0.0224 (408)1.42 (1.11–1.81)1.42 (1.06–1.90)0.236
 Colorectal only5 (552)0.52 (0.35–0.77)0.52 (0.35–0.77)0.4727 (858)1.42 (1.19–1.71)1.50 (1.11–2.02)0.0085 (596)1.70 (1.36–2.13)1.77 (1.11–2.84)0.002
  • aStudy: the number of studies included in the analysis.

  • bPhet: P value of between-study heterogeneity.