Table 2.

Univariate and multivariate analysis for overall survival (Cox proportional regression model)

FactorsUnivariate analysisMultivariate analysis
RR95% CIPRR95% CIP
Age (≤65/>66)0.9280.648–1.3140.673
Sex (male/female)0.8340.552–1.1210.345
Histology grade (well, moderately/poorly and others)1.3090.913–1.9460.146
Depth of tumor invasiona (m, sm, mp/ss, se, si)8.3872.531–51.860.0001b2.4150.650–15.870.208
Lymph node metastasis (negative/positive)4.6752.162–19.740.0001b2.8921.219–12.880.011b
Lymphatic invasion (negative/positive)2.6841.474–6.6760.0003b1.1770.481–5.2370.761
Venous invasion (negative/positive)3.3241.627–6.0800.0012b1.3160.883–1.9710.176
ERBB2 mRNA expression (low/high)1.4661.003–2.2630.0482b1.0100.991–1.0250.277
miR-125a-5p expression (high/low)3.0181.372–7.5880.0051b2.4381.035–6.7270.041b

Abbreviation: RR, Relative risk.

aTumor invasion of mucosa (m), submucosa (sm), muscularis propria (mp), subserosa (ss), penetration of serosa (se), and invasion of adjacent strucures (si).

bP < 0.05.