Table 1

Dosing schema and treatment duration

CohortStarting dose (mg/kg/day)No.of patientsDuration (treatment cycles)
10.530.8, 11, 4
21.031.7, 2, 2
31.531, 1.7, 2
42.061.3, 1.8, 2, 2, 4, 5
53.060.3, 0.5, 1.7, 2, 2, 7