Table 2

Pharmacokinetics of paclitaxel: main pharmacokinetic parameters of paclitaxel represented as means (±SD) after oral administration of a dose of 60 mg/m2 without and with administration of CsA and after a 3-h i.v. infusion of a dose of 175 mg/m2

PART II
Pharmacokinetic parameterPART I oral (n = 5)i.v. (n = 3)oral + CsA (n = 9)i.v. (n = 8)
AUC (μm·h)0.2 (±0.1)16.4 (±4.3)1.7 (±0.9)a17.1 (±3.7)
Cmaxm)0.1 (±0.0)4.5 (±0.9)0.2 (±0.1)a4.7 (±1.0)
Tmax (h)2.4 (±0.6)3.0 (±0.1)2.4 (±0.8)3.1 (±0.2)
T > 0.1 μm (h)15.0 (±3.8)3.7 (±2.3)17.2 (±3.5)
T > 0.05 μm (h)1.2 (±0.9)22.2 (±3.3)7.4 (±4.4)a28.1 (±8.9)
  • a P < 0.001 compared with oral paclitaxel without CsA.