Table 3

Pharmacokinetics of paclitaxel metabolites: main pharmacokinetic parameters of 6α-hydroxypaclitaxel, 3′p-hydroxypaclitaxel, and 6α3′p-dihydroxypaclitaxel in plasma, represented as means (±SD)

nTdet (h)Tmax (h)Cmaxm)AUC (μm·h)Ratio AUC metabolite: AUC paclitaxel
6α-hydroxypaclitaxel
 oral paclitaxel + CsA911.7 (±7.9)4.2 (±1.8)0.18 (±0.11)1.25 (±1.23)0.87
 i.v. paclitaxel87.4 (±9.0)3.2 (±0.2)0.37 (±0.34)1.05 (±1.29)0.06
3′p-hydroxypaclitaxel
 oral paclitaxel + CsA96.8 (±6.8)4.1 (±1.3)0.03 (±0.02)0.22 (±0.22)0.16
 i.v. paclitaxel87.6 (±8.8)3.3 (±0.2)0.14 (±0.11)0.56 (±0.71)0.03
6α,3′p-dihydroxypaclitaxel
 oral paclitaxel + CsA910.7 (±8.3)6.4 (±2.0)0.06 (±0.04)0.62 (±0.59)0.44
 i.v. paclitaxel85.7 (±9.5)3.7 (±0.5)0.18 (±0.31)0.67 (±1.38)0.04