Table 1

Effect of X-ray irradiation on up-regulation of dThdPase and tumor growth inhibition in several human cancer xenografts

Mice were given single-dose local X-ray irradiation on day 0. Tumor volume was measured on day 6 or day 9 after X-ray irradiation, and tumor tissues (n = 3) were excised to measure the levels of dThdPase.
dThdPase (units/mg protein) Mean ± SDTumor volume change (mm3) Mean ± SD
TumorRadiation dose (Gy)on day 6on day 9on day 6on day 9
WiDrControl1.0 ± 0.21.5 ± 0.2379 ± 190490 ± 149
2.53.3 ± 0.8a6.0 ± 0.3a255 ± 27489 ± 168
59.6 ± 3.7a19.5 ± 3.5a242 ± 44253 ± 41
HT-29Control1.8 ± 0.11.7 ± 0.1198 ± 14327 ± 39
2.55.2 ± 0.4a4.8 ± 0.4a201 ± 33233 ± 43a
510.1 ± 1.8a8.5 ± 0.8a97 ± 77181 ± 40a
MKN-45Control2.8 ± 0.12.8 ± 0.4351 ± 61399 ± 58
2.53.8 ± 0.3a3.6 ± 0.2a225 ± 108340 ± 99
54.6 ± 0.7a4.5 ± 0.3a241 ± 27a273 ± 37a
MX-1Control6.8 ± 1.1NDb1117 ± 246ND
2.518.0 ± 4.8aND540 ± 113aND
527.9 ± 4.8aND322 ± 202aND
SIHAControl60.6 ± 6.160.0 ± 11.3244 ± 104489 ± 152
2.567.3 ± 3.859.4 ± 3.3144 ± 170264 ± 88
555.3 ± 11.559.9 ± 4.991 ± 4864 ± 18a
  • a Significantly different from each control; P < 0.05 by Student’s t test.

  • b ND, not done.