Table 1

LOH at 4p14–16 in colorectal carcinomas in regard to lymph node invasion and mutations in the p53 genea

D4S2946D4S1551D4S2948D4S3022D4S2397D4S418D4S2912D4S1587D4S405Gross LOHb
LOH in informative cases28/157 (17.8)c30/168 (17.8)28/160 (17.5)30/168 (17.8)50/143 (35.0)30/146 (20.5)28/109 (25.7)28/142 (19.7)22/164 (13.4)25/181 (13.8)
Lymph node status
 N013/9614/10011/9814/10126/8515/9414/6315/828/979/108
 N16/397/4110/416/4213/396/318/318/387/416/45
 N2–N39/229/277/2110/2511/199/216/155/227/2610/28
P = 0.009NSdP = 0.02P = 0.007NSP = 0.02NSNSP = 0.03P < 0.001
p53 gene
 Wild-type6/605/695/664/6920/617/612/425/573/643/73
 Mutated15/6221/6614/5717/6419/5317/5614/4515/5513/6615/70
P = 0.05P < 0.001P = 0.01P = 0.001NSP = 0.02P = 0.002P = 0.01P = 0.01P = 0.002
  • a Number of cases with LOH respect the total number of informative cases.

  • b A gross LOH was considered when >60% of the informative markers displayed allelic imbalances.

  • c Numbers in parentheses, percentage of cases with LOH for a given marker.

  • d NS, not significant.