Table 2

In vivo studies of MBL

Tumor size (cm3)Analysis of slopea
Cell lineDay of analysisCompoundControlCompoundControl
A. Medulloblastoma therapeutic studiesb
D341151.98 ± 1.86 (n = 5)2.24 ± 0.790 (n = 5)0.199 ± 0.091 (n = 6)0.238 ± 0.068 (n = 6)
P = 0.60P = 0.75
DAOY161.51 ± 0.689 (n = 5)1.97 ± 0.603 (n = 3)0.152 ± 0.045 (n = 5)0.151 ± 0.069 (n = 3)
P = 0.39P = 0.96
D283391.044 ± 0.297 (n = 8)1.54 ± 0.51 (n = 8)0.017 ± 0.008 (n = 8)0.031 ± 0.012 (n = 8)
P = 0.031P = 0.021
B. Medulloblastoma prevention studyc
D341160.91 ± 0.92 (n = 5)2.17 ± 1.42 (n = 6)0.092 ± 0.072 (n = 8)0.186 ± 0.039 (n = 9)
P = 0.10P = 0.126
  • a Figures given for the average daily growth rate.

  • b Treatment started after tumors measured >0.24 g.

  • c Treatment commenced prior to tumor appearance.