Table 1A

Continued

TOPO 0.16/VCR 1
Versus VCR 10.009c
Versus TOPO 0.160.045
TOPO 0.24/VCR 1
Versus VCR 10.009c
Versus TOPO 0.240.63c
 SJ-GBM2Control707/72.3 (0.5)
VCR 1716/68.8 (2.5)0.009
TOPO 0.36743/39.7 (3.5)0.009
TOPO 0.6707/76.4 (1.0)0.009
TOPO 0.36/VCR 1700/70.009
TOPO 0.6/VCR 1710/60.009
TOPO 0.36/VCR 1
Versus VCR 10.009c
Versus TOPO 0.360.009c
TOPO 0.6/VCR 1
Versus VCR 10.009c
Versus TOPO 0.60.009c
  • a VCR, vincristine; TOPO, topoisomerase I.

  • b Number of censored mice. Censored implies that the mouse died prior to week 12 and before the tumor grew to four times initial volume.

  • c Combination therapy shows statistically significant (P ≤ 0.05) improvement over individual agent.