Table 2

AUCa of organs in C-26 tumor-bearing BALB/c mice after 10 mg/kg liposomal doxorubicin injection

PlasmaTumorHeartLiverSpleenLungKidneySubcutis
NPLDb
 24 h1889637318900376127485308
 72 h25862255969278123875721552986
PLD
 24 h3206541306685259132782231
 72 h5136157089818619164312138725
NPLD/PLD
 24 h0.591.181.041.311.450.960.621.34
 72 h0.501.441.081.492.611.330.731.36
  • a AUC (h · mg/g) calculations over 0–72 h (n = 3–5) by the trapezoid method. Plasma AUC is given as h · mg/ml (n = 5).

  • b NPL, non-PEGylated liposomal doxorubicin; PLD, liposomal doxorubicin with 6% PEG-modified lipid.