Table 2

Toxicity profile initial single injection (part 1)

Dose level (μg/kg)No. of patientsHemoglobinLeukopeniaGranulopeniaLymphopeniaThrombopenia
12341234123412341234
0.1300001100100002100000
0.5630000110010015000000
1.0430000310120012014000
0.512a20003230323035212000
  • a After defining MTD for the initial injection, the additional patients enrolled to define MTD for repeated injections received their initial injection at a dose of 0.5 μg/kg.