Table 3

Toxicity profile initial single injection (part 2)

Dose level (μg/kg)No. of patientsFeverFatigueHeadacheNauseaVomiting
12341234123412341234
0.1310001000100000000000
0.5615002100010000000000
1.0403101300200030002000
0.512a39001100600040002100
  • a After defining MTD for the initial injection, the additional patients enrolled to define MTD for repeated injections received their initial injection at a dose of 0.5 μg/kg.