Table 4

Results of univariate and multivariate analyses using the Cox regression analysis model

	Univariate^a			Multivariate^b
	log likelihood ratio	Partial^cP	Combination of two factors	log likelihood ratio	Partial P	Combination of three factors	log likelihood ratio	Partial P	Combination of all four factors	log likelihood ratio	Partial P
HER-2/neu	−19.20	<0.001	HER-2/neu+HER-3	−13.94	<0.002	HER-2/neu+HER-3+EGFR	−11.99	<0.05	HER-2/neu+HER- 3+EGFR+HER-4	−11.66	>0.25
HER-4	−19.54	<0.001	HER-2/neu+HER-4	−16.84	<0.05	HER-2/neu+HER-3+HER-4	−13.82	>0.5
HER-3	−20.72	<0.001	HER-2/neu+EGFR	−18.35	>0.25
EGFR	−25.75	<0.001

^a Addition of single oncoprotein to Cox regression analyses, which includes histological grade, nodes, and distant metastasis.
^b Multivariate addition of oncoproteins to Cox regression analysis, which includes histological grades, nodes, and distant metastasis.
^c Log likelihood relative to log likelihood of −36.0 for grade, nodal stage, and distant metastasis.