Table 2

Effect of docetaxel (DOC) on radioresponse of SCC-VII cells measured by tumor growth delay

TreatmentaTumor growth delay
Time in days required for tumor to grow from 8 to 12 mmbAGDcNGDdEFse
No treatment3.8 ± 0.3
DOC (single)3.8 ± 0.20
25 Gy XRT (single)f7.1 ± 0.33.3 ± 0.3
DOC (single) + XRT (single)7.9 ± 0.74.1 ± 0.74.1 ± 0.71.24
DOC (multiple)5.9 ± 1.02.1 ± 1.0
5 Gy XRT × 5 (fractionated)5.7 ± 0.31.9 ± 0.3
DOC (single) + XRT (fractionated)6.8 ± 0.23.0 ± 0.23.0 ± 0.21.58
DOC (multiple) + XRT (fractionated)9.7 ± 0.55.9 ± 0.53.8 ± 0.52.0
  • a Mice bearing 8-mm tumors in the right legs were given i.v. docetaxel as a single dose of 33 mg/kg or as five daily doses of 8 mg/kg and/or local tumor irradiation.

  • b Mean ± SE.

  • c AGD, days for tumors in treated groups (DOC or radiation) to grow from 8 to 12 mm minus the time for tumors in the untreated control group to reach the same size.

  • d NGD, time for tumors treated with both DOC and radiation to grow from 8 to 12 mm minus the time for tumors treated with DOC alone to reach the same size.

  • e EF, ratio of NGD for tumors treated with DOC plus radiation to AGD for tumors treated with radiation alone.

  • f XRT, radiation.