Table 5

Median and range of neutrophil count nadir (× 109/liter) and time to nadir (days)

Dose (mg/m2 dox-eq)aNo. of patients/dose levelNo. of evaluable cyclesMedian neutrophil nadir (range)Median time to nadir (range)
20365.9 (2.9–7.5)15 (8–21)
40344.9 (2.6–6.1)14 (7–21)
803123.71 (2.9–6.1)21 (1–21)
1203186.87 (3.3–9.5)21 (1–21)
1806173.3 (1.0–5.4)15 (15–21)
2406152.2 (0.6–3.7)15 (15–21)
280619b1.8 (0.5–3.4)15 (7–21)
32069c1.4 (0.02–5.42)15 (15–21)
  • a dox-eq, doxorubicin-equivalent.

  • b Includes two cycles from patient initially treated at 240 mg/m2 for two cycles and then dose-escalated. One cycle was only to d 15.

  • c One cycle was only to d15. Three of nine cycles at this level were associated with febrile neutropenia (see text).