Table 1

Effect of rhIL-12 therapy on absolute lymphocyte counts of cancer patients

rhIL-12 dose cohort (n)Total absolute lymphocyte count (cells/μl)aPb
Before rhIL-12After rhIL-12
3 ng/kg (3)1533 ± 4511267 ± 306≤0.05
10 ng/kg (4)950 ± 545750 ± 507≤0.05
30 ng/kg (4)2725 ± 10371350 ± 968≤0.05
100 ng/kg (3)1400 ± 755300 ± 100≤0.05
250 ng/kg (6)1900 ± 857380 ± 130≤0.001
500 ng/kg (13)1731 ± 992338 ± 229≤0.0005
1000 ng/kg (3)1533 ± 306333 ± 231≤0.025
  • a Values are the mean ± SD of the absolute number of lymphocytes just before and approximately 24 h after a single i.v. injection of rhIL-12 at the indicated dose. The normal range for the absolute lymphocyte count in the reference laboratory used is 800–4800 cells/μl.

  • b P are from the paired Student’s t test.