Table 3

Effect of rhIL-12 therapy on serum IFN-γ levels

Values are the mean ± SD of the IFN-γ levels in the serum of patients treated at the indicated dose levels of rhIL-12. Serum was isolated from blood drawn just before, 24 h after, or 7 days after single i.v. bolus injections of rhIL-12 as indicated. The lower limit of detection for the assay was 10 pg/ml; a value of 10 pg/ml was used for samples with undetectable levels of IFN-γ.
Serum IFN-γ level (pg/ml)
rhIL-12 dose cohort (n)Before rhIL-1224 h after rhIL-127 days after rhIL-12
3 ng/kg (4)10 ± 017 ± 1510 ± 0
10 ng/kg (4)10 ± 026 ± 1410 ± 0
30 ng/kg (4)10 ± 0338 ± 45010 ± 0
100 ng/kg (4)10 ± 0679 ± 38810 ± 0
250 ng/kg (6)11 ± 32096 ± 64512 ± 3a
500 ng/kg (14)44 ± 1265443 ± 715010 ± 1
1000 ng/kg (4)10 ± 09119 ± 395216 ± 11
  • a Results were available for five patients only.