Table 2

Induction of G1 cell cycle arrest and apoptosis in mammary tumor biopsies by l-744,832

A. Flow cytometric analysis
n = 6% cells in cell cycle fraction ± SE
G1SG2-M
Before FTI67 ± 3.95.6 ± 1.422 ± 4.2
After FTI80 ± 1.12.6 ± 0.615 ± 0.7
B. Apoptosis assay
n = 9% apoptotic cells
Before FTI0.16 ± 0.11
After FTI2.57 ± 0.31