Table 2

Mean pharmacokinetic parameters: compartmental analysis for TEM, MTIC, and AIC in plasma

ParameterUnitMean% CV
Tlaghr0.5228
kahr−13.095
Vc/Fliter/m21725
Vd,AIC/Fliter/m23551
Cls,TMZ/Fml/min/m210821
Cls,MTIC/Fml/min/m2538458
Cls,AIC/Fml/min/m241044
Cld,AIC/Fml/min/m21908120
t1/2,TMZhr1.87.5
t1/2,MTICmin2.530
Ratio of Cls,TMZ/F:Cls,MTIC/F0.02328
Ratio of Cls,TMZ/F:Cls,AIC/F0.2216