Table 1

Clinical findingsa

PatientPTXb doseBCNUBrain metastasesPrior WBIOther toxicitiesClinical pictureOnset (day)Brain MRIOutcomeBrain autopsy
1600200YesYesLiver G3Coma+2NormalDeathDiffuse WM atrophy
2600550NoNoMucositis G3; ileus G3Coma+10NormalResolutionN/A
3775200NoNoLungs G4Coma+5NormalResolutionN/A
4775NoNoMucositis G3; liver G3Coma+16Multiple small infarctsDeathMultiple small infarcts
5825YesYesMucositis G3; renal G3Coma+3Diffuse WM atrophyDeathNot authorized
6825NoNoRenal G3Severe confusion0NormalResolutionN/A
  • a Doses are given in mg/m2.

  • b PTX, paclitaxel; WM, white matter; N/A, not applicable.