Table 2

Frequency of metastasis—16 weeks

CloneLungLiverPeritoneumBrainBone marrow
HPCA-10a parent1/20a2/206/200/201/20
2 ± 1b4 ± 14 ± 1NDc1 ± 0
HPCA-10a IL-10-Mock1/203/206/200/201/20
3 ± 15 ± 15 ± 1ND1 ± 0
HPCA-10a2/202/203/201/201/20
IL-103 ± 13 ± 14 ± 2ND2 ± 1
HPCA-10a1/202/205/200/201/20
TGF-β Mock5 ± 14 ± 13 ± 1ND1 ± 0
HPCA-10a5/207/2014/201/202/20
TGF-β113 ± 323 ± 614 ± 3ND2 ± 1
HPCA-10a1/205/205/200/201/20
IL-10 and TGF-β13 ± 15 ± 12 ± 1ND1 ± 0
HPCA-10a1/205/205/200/201/20
IL-10 and TGF-β1 Mock4 ± 14 ± 13 ± 1ND1 ± 0
  • a The number of mice with tumor metastases of 20 mice examined.

  • b The average number of tumor foci detected per organ site. Values represent the average ± 1 SD from six measurements/experiment.

  • c ND, not done.