Table 3

IC50 of cisplatin and DACH-acetato-Pt in control clone PVC1 and HPV E6 clone E6B2 from OVCA-429 cells and corresponding resistance factors for E6B2a

ParameterContinuous drug exposure2-h drug exposure
CisplatinDACH-acetato-PtCisplatinDACH-acetato-Pt
IC50, PVC16.41 ± 0.83b1.04 ± 0.1722.2 ± 2.065.26 ± 0.50
IC50, E6B26.73 ± 1.542.55 ± 0.58c23.6 ± 2.8526.3 ± 2.55c
Resistance factor1.03 ± 0.193.25 ± 1.11d1.06 ± 0.094.99 ± 0.12d
  • a Resistance factor of E6B2 = (IC50 vs. E6B2)/(IC50 vs. PVC1).

  • b Mean ± SE; n = 3–7.

  • c Significantly different from PVC1 (P < 0.05).

  • d Significantly different from 1.00 (P < 0.05).