Table 2

Numbers of patients and paclitaxel Css according to paclitaxel treatment arm

Paclitaxel treatment armaP
PCPCG
No. of patients randomized in ECOG study 5592 (eligible and treated)201 (187)198 (190)
No. of patients with plasma samples in course 1101102
 Mean (SD) paclitaxel Css (μmol/liter)0.44 ± 0.551.03 ± 0.69
 Median (range)0.32 (0.10–4.63)0.85 (0.15–4.53)<0.0001
No. of patients with plasma samples in course 27887
 Mean (SD) paclitaxel Css (μmol/liter)0.41 ± 0.560.91 ± 0.75
 Median (range)0.25 (0.04–3.64)0.75 (0.07–4.97)<0.0001
No. of patients with plasma samples in courses 1 and 27175
 Mean (SD) paclitaxel Css,avg (μmol/liter)0.44 ± 0.450.94 ± 0.59
 Median (range)0.32 (0.12–3.70)0.81 (0.11–3.60)<0.0001
  • a Treatment arms: PC, 75 mg/m2 i.v. cisplatin on day 2 preceded by 135 mg/m2 paclitaxel over 24 h i.v. on day 1; PCG, 75 mg/m2 i.v. cisplatin on day 2 preceded by 250 mg/m2 i.v. paclitaxel over 24 h on day 1 plus G-CSF 5 μg/kg starting on day 3.