Table 1

Tumorigenicity and production of metastasis by LNCaP cells and two variants subsequent to orthotopic implantation in atymic nude mice

LNCaP cell lineTumorigenicityProstate weight, g (mean ± SD)Para-aortic lymph node metastases
LNCaP24/431.2 ± 1.012/43
LNCaP-Pro510/173.3 ± 1.7a2/17
LNCaP-LN319/19b1.2 ± 0.913/19c
  • a P < 0.05, compared with LNCaP and LNCaP-LN3.

  • b P < 0.001, compared with LNCaP; P = 0.002, compared with LNCaP-Pr05.

  • c P < 0.003, compared with LNCaP; P < 0.001, compared with LNCaP-Pr05. Adapted from Pettaway et al. (21) .