Table 1

Inhibition of nontransduced H226Br tumor cell growth by mixed wt-p53 gene-transduced cells

Cell no.aMean volume ± SD (mm3)b
Days after tumor inoculation
No. of mice with tumor/total no. of miceH226BrH226Br + Ad-p5314212835
6/6106100.1 ± 53.8266.2 ± 140.0561.5 ± 339.71111.0 ± 635.1
5/51062 × 10553.8 ± 26.1118.6 ± 52.6282.2 ± 98.8551.5 ± 227.0
5/51065 × 10540.2 ± 17.174.3 ± 31.2167.0 ± 74.0331.7 ± 150.5c
6/610610624.1 ± 18.937.6 ± 30.7115.8 ± 56.9269.5 ± 125.6c
2/61060033.9 ± 13.771.9 ± 26.5d
  • a Nontransduced H226Br cells were mixed with H226Br cells infected with Ad5CMVp53 (30 MOI).

  • b Mixed H226Br cells were s.c. injected into nu/nu mice. Perpendicular diameters were measured, and tumor volume was calculated at the indicated time.

  • c P < 0.05 by Student’s t test when compared to the control group.

  • d P < 0.01 by Student’s t test when compared to the control group.