Table 2

Amount of SN-38 produced in situ in U373pIRESrabbit and U373pIREShuman cells incubated with 250 μm CPT-11

Results of three individual experiments are shown.
pg of SN-38/350 units of CE activityRelative efficiency
U373pIRESrabbitU373pIREShumanrabbit/human
489726.8
134168.6
23935 6.6
7.4 + 1.1a
  • a Mean + SD of the relative efficiency of the rabbit compared with the human enzyme.