Table 5

Comparison of LOH and MA frequencies between successfully cultured and uncultured (sporadic) lung carcinomas

Molecular abnormalityCultured tumors(n = 12)Uncultured tumors(n = 40)P
LOH
 3p253/8 (38%)17/30 (57%)0.28
 3p22–246/11 (55%)27/40 (68%)0.33
 3p217/12 (58%)25/40 (63%)0.53
 3p14–212/9 (22%)15/27 (56%)0.08
 3p14.2 (FHIT gene)4/10 (40%)26/39 (67%)0.12
 3p122/8 (25%)23/37 (62%)0.06
 Any 3p8/12 (67%)33/40 (83%)0.22
 5q22 (APC-MCC region)4/9 (44%)3/26 (12%)0.50
 8p2310/11 (91%)27/40 (68%)0.12
 8p2210/12 (83%)21/38 (55%)0.80
 8p217/12 (58%)27/40 (68%)0.41
 Any 8p12/12 (100%)36/40 (90%)0.41
 9p217/9 (78%)20/31 (65%)0.30
 13q (RB gene)2/6 (33%)8/21 (38%)0.36
 17p (TP53 gene)7/9 (78%)13/19 (68%)0.47
FAL indexa mean  (range)0.45 (0.19–0.75)0.49 (0.05–1.0)0.86
MA frequency5/12 (39%)18/40 (45%)0.55
MA indexa mean (range)0.026 (0–0.13)0.030 (0–0.17)0.40
  • a Indicator of LOH at all microsatellite markers (n = 37) analyzed by case (range, 0–1).