Table 1

Enrollment, dose-limiting toxicity, average change in serum calcium, and change in urine calcium (pretherapy vs. day 28) by dose level

Calcitriol dose (μg)No. of patientsNo. of patients with DLTaAverage maximum serum calcium (mg/dl)Fold change in 24-h urine calcium, pretherapy vs. day 28
261+0.2ND
340−0.2ND
431+0.8ND
572+1.2ND
640+0.4ND
740−0.310, 3, 9
850+0.94, 2
1033+1.98, 5, 7
  • a DLT, dose-limiting toxicity; ND, not determined.