Table 2

Pharmacokinetic parameters of s.c. calcitriol on day 1 and day 7a

Dose (μg)Tmax (h)Cpmax (pg/ml)Css (pg/ml)AUC0–12 h (pg · h/ml)T1/2 (min)Vdss (liters)
nDay1Day 7Day 1Day 7Day 1Day 7Day 1Day 7Day 1Day 7Day 1Day 7
220.9 ± 0.32.3 ± 0.5112 ± 1698 ± 1684 ± 1587 ± 13846 ± 42891 ± 10410.6 ± 2.116.1 ± 3.022.6 ± 2.117.7 ± 4.7
351.1 ± 0.10.9 ± 0.1143 ± 22121 ± 16116 ± 1798 ± 121112 ± 184876 ± 14613.5 ± 8.711.2 ± 8.225.0 ± 8.430.6 ± 9.7
432.7 ± 0.92.2 ± 0.6198 ± 39196 ± 15170 ± 36178 ± 221900 ± 4261717 ± 27819.2 ± 8.49.9 ± 1.325.0 ± 9.018.0 ± 2.4
572.5 ± 0.42.6 ± 0.4186 ± 18186 ± 36154 ± 17141 ± 191552 ± 1951447 ± 22714.9 ± 10.011.8 ± 3.629.9 ± 16.331.3 ± 11.1
642.8 ± 0.51.9 ± 0.4301 ± 52287 ± 24246 ± 33231 ± 302565 ± 3512406 ± 26014.9 ± 9.512.5 ± 3.222.1 ± 9.825.8 ± 15.1
731.2 ± 0.51.2 ± 0.6260 ± 31246 ± 42270 ± 31208 ± 262324 ± 2701725 ± 17311.8 ± 2.17.0 ± 0.222.2 ± 6.025.0 ± 0.1
842.1 ± 0.51.0 ± 0.0295 ± 51311 ± 62259 ± 37240 ± 562648 ± 3112324 ± 35317.5 ± 4.810.9 ± 5.025.6 ± 8.129.5 ± 12.8
1031.7 ± 0.72.5 ± 0.5288 ± 42321 ± 36260 ± 39269 ± 172534 ± 4102605 ± 32714.0 ± 3.710.5 ± 3.232.2 ± 9.221.0 ± 3.2
  • a Values are mean ± SE.