Table 4

Secretion of cytokines by UMSCC cell lines

Cytokinesb,c
ProinflammatoryProangiogenic
Cell linesaIL-1αIL-6IL-8GM-CSFVEGFBasic FGF
UMSCC-1+++c++++++++++++++
UMSCC-9+++++++++++++++++
UMSCC-11A++++++++++++++++++++
UMSCC-11B+++++++++++++++++++++++
UMSCC-22A+++++++++
UMSCC-22B+++++++++
UMSCC-38++++++++++++
  • a UM-SCC (University of Michigan) cell lines.

  • b Picograms/106 cells/48 h. +, 1–10; ++, 10–100; +++, 100–1,000; ++++, 1,000–10,000.

  • c Proinflammatory cytokines, IL-1β, TNF-α, TGF-β, and immunoregulatory cytokines IL-2, IL-12, γ-IFN, IL-4, and IL-10 were also screened in UM-SCC cell lines. The cell lines did not produce significant detectable levels of the cytokines.