Table 5

Secretion of cytokines by primary head and neck SCC lines

Cytokinesa
ProinflammatoryProangiogenic
Cell lineIL-1αIL-6IL-8GM-CSFVEGFBasic FGF
NIH-SCC-1++++++++++++NDbND
NIH-SCC-2++++++++++++NDND
NIH-SCC-3+++++++++++++NDND
NIH-SCC-4Ac++++++++++++NDND
NIH-SCC-4B++++++++++++NDND
NIH-SCC-7++++++++++++++
NIH-SCC-8Ad++++++++++++++++++
NIH-SCC-8B++++++++++++
NIH-SCC-9++++++++++++++++++
  • a The level of cytokine production in the supernatants was shown as picograms/ml/48 h. +, 1–10; ++, 10–100; +++, 100–1,000; ++++, 1,000–10,000.

  • b ND, not done.

  • c 4A and 4B primary cultures were isolated from the biopsy (A) and surgery (B) specimens.

  • d 8A and 8B primary cultures were isolated from the primary tumor site (A) and lymph node metastasis (B).