Table 3

Pharmacokinetic parameters after a 3-h infusion of paclitaxel in 34 cancer patientsa

Dose (mg/m2)nCmaxbm)AUCm·h)T1/2 (h)CL(liter/h/m2)MRT(h)VdSS (liter/m2)
10032.0 ± 0.37.0 ± 0.84.0 ± 0.717.1 ± 2.34.9 ± 0.758.3 ± 14.4
13564.8 ± 0.712.2 ± 1.83.3 ± 0.214.4 ± 1.73.9 ± 0.233.6 ± 4.1
17065.8 ± 0.615.7 ± 1.43.0 ± 0.213.3 ± 1.03.8 ± 0.329.4 ± 3.7
20078.7 ± 1.023.2 ± 2.03.6 ± 0.310.5 ± 1.34.0 ± 0.226.6 ± 4.0
225612.3 ± 1.130.8 ± 2.83.7 ± 0.39.1 ± 1.04.3 ± 0.224.7 ± 3.4
250614.3 ± 1.938.6 ± 5.52.8 ± 0.38.3 ± 1.13.9 ± 0.220.2 ± 4.1
  • a Mean values ± SE.

  • b Cmax, the maximum (paclitaxel concentrations); T1/2, half-life in hours; CL, total body clearance; MRT, mean residence time.