Table 1

Patient characteristics

Cohort I (n = 22)Cohort II (n = 13)
Median Age (yr; range)71.5 (58–83)71.0 (63–89)
Median KPS (range)80% (60–100%)90% (60–100%)
Median pretreatment PSA (ng/ml; range)276 (192–3676)81 (8.9–240)
Median pretreatment hemoglobin (g/dl)12.012.7
Patients with positive bone scan21/22 (96%)10/13 (77%)
Patients with measurable disease11/22 (50%)2/13 (15%)
Patients with measurable disease only1/22 (05%)1/13 (08%)
Prior systemic therapy
 Chemotherapy or suramin13/22 (59%)4/13 (31%)
 Patients with ≥ three prior hormone treatments21/22 (95%)11/13 (85%)