Table 1

Demographic parameters of patients with normal liver function (Group 1) and patients with mild to moderate hepatic dysfunction (Group 2)

Values are given as arithmetic means (± SD) and range.
Group 1 Patients with normal liver function (n = 17)aGroup 2 Patients with liver dysfunction (n = 16)b
Demographic data
 Age (years)59 ± 13.9 (34–84)62 ± 10.9 (44–84)
 Weight (kg)66.9 ± 16.8 (45–94)67.4 ± 10.4 (44–84)
 Body surface area (m2)1.76 ± 0.23 (1.49–2.22)1.79 ± 0.15 (1.41–2.00)
 Sex (males/females)10/712/4
 Race (Caucasian)1716
 Karnofsky status (%)85.3 ± 11.2 (60–100)76.7 ± 11.1 (60–90)
Liver functionc
 Hepatic dysfunction score (points)0–25–9
 Total BILI (μmol/liter)12 ± 5.9 (4–27)112 ± 153 (16–485)
 AST (IU/liter)39.5 ± 41.9 (6–171)107 ± 34.1 (46–174)
 ALT (IU/liter)27.1 ± 15.4 (7–58)112 ± 94.0 (19–341)
 AP (IU/liter)231 ± 150 (76–511)1816 ± 1096 (370–3233)
  • a Evaluated for pharmacokinetics n = 14.

  • b Evaluated for pharmacokinetics n = 13.

  • c Patients evaluated for pharmacokinetics.