Statistical analysis of the effect of hepatic dysfunction on the primary and secondary kinetic parameters of capecitabine and its metabolites after a single oral administration of 1255 mg/m2 capecitabine using the log transformation
| Backtransformed least squares means | Change (%) | ||||||
|---|---|---|---|---|---|---|---|
| Parameter and analytes | Normal hepatic function | Hepatic dysfunction | Estimate | 95% CI | Test for group difference, P | ||
| AUC0–∞ | |||||||
| Capecitabine | 7.25 | 10.7 | 48.2 | −3.95 –128.6 | 0.073 | ||
| 5′-DFCR | 14.1 | 9.16 | −35.2 | −52.6 –−11.3 | 0.009 | ||
| 5′-DFUR | 11.7 | 14.0 | 19.5 | −4.08 –48.9 | 0.108 | ||
| 5-FU | 0.53 | 0.61 | 15.1 | −12.95 –52.2 | 0.310 | ||
| FBAL | 51.1 | 63.2 | 23.6 | −22.9 –98.2 | 0.353 | ||
| C max | |||||||
| Capecitabine | 3.95 | 5.91 | 49.5 | −15.6 –164.7 | 0.160 | ||
| 5′-DFCR | 5.02 | 3.53 | −29.8 | −52.6 –4.07 | 0.076 | ||
| 5′-DFUR | 4.64 | 6.19 | 33.4 | −8.95 –95.4 | 0.133 | ||
| 5-FU | 0.22 | 0.28 | 28.3 | −18.8 –102.9 | 0.272 | ||
| FBAL | 6.22 | 6.74 | 8.28 | −17.8 –42.6 | 0.557 | ||