Table 1

pRb expression during multistage colorectal carcinogenesis

In the polyps group of samples, the percentage of pRb-positive cells showed no significant correlation with the following clinicopathologic parameters: location in the colorectum (right side, transverse, left side, or rectum), size (<10 mm, 10–20 mm, or >20 mm), shape (pedunculate, pseudosessile, or sessile), histology (tubular or tubulo-villous). In the carcinomas group of samples, the percentage of pRb-positive cells showed no significant correlation with tumor size (<3.9 cm or >4.0 cm), depth of invasion, Dukes‘ stage, site, or metastasis to lymph nodes or the liver.pRb expression (% of cells positive)
<10%10–50%>50%Total
Normal mucosa50 (100%)0050
Adenomatous polyps36 (72%)10 (20%)4 (8%)50
Focal cancers in adenomatous polyps2 (13%)6 (40%)7 (47%)15
Carcinomas11 (22%)22 (44%)17 (34%)50