Table 1

RT-PCR and DNA PCR methods for the detection of occult tumor cells in solid tumors

Tumor typeMolecular target
MelanomaTyrosinase mRNA
MART 1 mRNA
ProstatePSA mRNA
PSMA mRNA
PTI-1 mRNAa
Breast carcinomaMuc 1 mRNA
CEA mRNA
Cytokeratin 19 mRNA
Hepatocellular carcinomaAFP mRNA
Albumin mRNA
Gastrointestinal carcinomasK-ras mutationsa
CEA mRNA
NeuroblastomaTyrosine hydroxylase mRNA
PGP 9.5 mRNA
GAGE mRNAa
EWSEWS/FLI1 fusion transcripta
EWS-ERG fusion transcripta
Uterine cervix carcinomaSCC antigen mRNA
HPV E6 mRNAa
Thyroid carcinomas of follicularTGB mRNA
 originTPO mRNA
  • a Except for these molecules, all other markers are tissue specific. PGP 9.5, neuroendocrine protein gene product; SCC, squamous cell carcinoma; HPV, human papilloma virus.