Table 5

Molecular prognosis in melanoma using RT-PCR

The relative risk was not available in all the above references. However, in each article RT-PCR positivity correlated with poorer survival time. Only those articles using Kaplan-Meier survival analysis are included in this table. In the article by Curry et al.(80) , the samples were tested for tyrosinase and Mart 1. RT-PCR positivity was defined as positivity for any of the markers.
Author (Ref.)AJCC stageaMarkerSampleEnd pointP
Mellado et al. (79)II–IIITyrosinaseBloodDFS<0.05
Kunter et al. (75)IVTyrosinaseBloodOS≤0.0006
Ghossein et al. (34)IITyrosinaseBloodOS0.01
IITyrosinaseBMOS0.06
IIITyrosinaseBloodOS0.02
Curry et al. (80)I–IIITyrosinase/Mart 1BloodDFS0.0022
  • a Stage I, primary tumor <1.5 mm in thickness with no metastases; stage II, primary tumor >1.5 mm in thickness with no metastases; stage III, regional lymph node metastases; stage IV, distant metastases.

  • b DFS, disease-free survival; OS, overall survival.