Table 1

Effects of AG3340, carboplatin, or a combination of AG3340 and carboplatin on tumor growth and animal body weights across studies

Agent	Dose	Percent tumor growth inhibition^a	Percent body weight change^b	n^c
Control vehicle		0	−8.8	3
AG3340	(mg/kg/day)
	100	32.1	−3.9	2
	200	39.4	+0.3	2
	400	60.3	−6.0	2
Carboplatin	(mg/kg/wk)
	20	13.4	−9.6	2
	40	29.4	−24.5	2
	60	55.6	−9.0^d	1
	120	64.8	−21.9	1
AG3340	100
+	+	39.1	−14.6^e	1
Carboplatin	20
AG3340	100
+	+	49.4	−16.5^e	1
Carboplatin	40
AG3340	400
+	+	62.2	−13.0^e	1
Carboplatin	40

^a Mean value on day 38 relative to controls.
^b Mean value on day 38 relative to starting weight on day 3–5 before treatment began.
^c n, number of studies (with 10–12 animals/group and two tumors/animal).
^d Control animals matched to this group did not suffer weight losses in this particular study (−0.5%, P > 0.05).
^e Control animals corresponding to this group lost 14.9% body weight in this study (shown in Fig. 6)<$REFLINK> .