Table 1

Effects of AG3340, carboplatin, or a combination of AG3340 and carboplatin on tumor growth and animal body weights across studies

AgentDosePercent tumor growth inhibitionaPercent body weight changebnc
Control vehicle0−8.83
AG3340(mg/kg/day)
10032.1−3.92
20039.4+0.32
40060.3−6.02
Carboplatin(mg/kg/wk)
2013.4−9.62
4029.4−24.52
6055.6−9.0d1
12064.8−21.91
AG3340100
  ++39.1−14.6e1
Carboplatin20
AG3340100
  ++49.4−16.5e1
Carboplatin40
AG3340400
  ++62.2−13.0e1
Carboplatin40
  • a Mean value on day 38 relative to controls.

  • b Mean value on day 38 relative to starting weight on day 3–5 before treatment began.

  • c n, number of studies (with 10–12 animals/group and two tumors/animal).

  • d Control animals matched to this group did not suffer weight losses in this particular study (−0.5%, P > 0.05).

  • e Control animals corresponding to this group lost 14.9% body weight in this study (shown in Fig. 6)<$REFLINK> .