Table 3

Summary of immune responses to MUC1 in immunized chimpanzees

T-cell responses
Identification no.ProliferationaIFN-γ expressionbCTL functioncAb responsesd
575+NT
638++++NT
654+++NT
664+++++
  • a SI: + ≥2.5 at one time point; ++, ≥2.5 at two time points; +++, ≥5.0 at two time points.

  • b −, not detected; +, 1–2% IFN-γ+ cells; ++, 3–6% IFN-γ+ cells.

  • c NT, not tested; +, CTL function detected following immunization.

  • d Sera tested by ELISA (6). −, not detected. Ab, antibody.