Table 4

ERBB2 amplificationa

TumorAmplification (%)Cases studiedMethodReference
Bladder331FISH/ArraySchraml et al.
424SouthernMellon et al. (75)
7141FISHSauter et al. (76)
1135PCRGorgoulis et al. (77)
2692PCROrlando et al. (78)
Breast671FISH/ArraySchraml et al.
17178SouthernProst et al. (79)
19539SouthernBorg et al. (80)
2263SouthernKnyazev et al. (81)
2344FISHKallioniemi et al. (82)
2470PCRAn et al. (83)
26195PCRAn et al. (84)
35101DotBlotChen et al. (85)
Carcinoidb03FISH/ArraySchraml et al.
Colon330FISH/ArraySchraml et al.
519SouthernKnyazev et al. (81)
3023PCRWang et al. (86)
DCIS2715FISHMurphy et al. (87)
676FISH/ArraySchraml et al.
Endometrium011FISH/ArraySchraml et al.
450SouthernEsteller et al. (14)
6372PCRCzerwenka et al. (15)
Head/Neck00FISH/ArraySchraml et al.
066SouthernLeonard et al. (58)
021SouthernMerritt et al. (59)
1811 cell linesSouthernBeckhardt et al. (88)
Kidney013SouthernFreeman et al. (89)
015SouthernSato et al. (90)
034SouthernStumm et al. (91)
023FISH/ArraySchraml et al.
1770PCRZhang et al. (92)
Lung034SouthernKnyazev et al. (81)
175FISH/ArraySchraml et al.
251SouthernShiraishi et al. (93)
329SouthernBongiorno et al. (94)
Melanoma03SouthernKnyazev et al. (81)
04FISH/ArraySchraml et al.
Ovary025FISH/ArraySchraml et al.
423SouthernKnyazev et al. (81)
1465SouthernFajac et al. (95)
3126SouthernFan et al. (96)
6447ISHHou et al. (97)
Phylloidesb04FISH/ArraySchraml et al.
Prostate015SouthernFournier et al. (16)
021SouthernLatil et al. (18)
018FISH/ArraySchraml et al.
4462FISHRoss et al. (19)
Stomach634SouthernKameda et al. (98)
650SouthernRanzani et al. (69)
669SouthernTsujino et al. (99)
1811FISH/ArraySchraml et al.
Testisb017FISH/ArraySchraml et al.
Thyroid03FISH/ArraySchraml et al.
427SouthernKnyazev et al. (81)
  • a Studies on metastatic samples or tumors from treated patients were excluded.

  • b No data in the literature were found for phylloides tumors, carcinoids, pheochromocytomas, or tumors of the testis.